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My opinion....Telling the truth from the beginning would be really the best advice you can give to your sister.
There is a great probability of your niece finding it out sometime and that would be very harmfull not just for her, but for everyone involved.
Ask your sister to inform herself a little more about adoption. We can always learn from others´experiences, so that we try not to make the same mistakes..
Good luck!
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Mother in waiting
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