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From my perspective (I was the first parented child after my mom placed my sister for adoption) I think it DID affect her. This was back in the day when adoption was a huge shame, and certainly not something she would talk about or get help or support for. She over compensated for her own perceived failure for losing my sister by being the PERFECT mother to my younger sister and I . She was super protective, super involved, super human in her mothering for the first 12-15 years of our lives. About that time -- when we started to individualate from her, she panicked and replaced us with a very disfunctional - highly needy - partner. And essentially, because we became independent, I think she emotionally responded by viewing it as rejection, or loss again.
Its severely affected our adult relationships with her. HOWEVER, strangely enough, because she WAS such a great mom when we were younger, I really think it resulted in my younger sis and I having the emotional skills to deal with it. If that makes any sense at all ...
From what my mom has told me -- she was VERY protective of us as babies. Didnt want or let anyone else to hold us. Was extremely sensitive to any criticisms of her parenting and as such appeared to be perfect to others. Huge pressure on herself to never lose her patience etc.
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Jensboys
Mom of 4 Boys (2 adopted, 2 biological) 
Reunited Sister
BOYS definition (noun) : Noise with dirt on top
'Oh, the audacity of authenticity. You’re going to confuse, piss-off and terrify lots of people – including yourself. You're going to pray it ends, then pray it never ends.' -- Brené Brown |